Juha Kere

The paper identifies PE-dependent genetic regulation at promoters using cis-eQTL analysis of placental RNA sequencing data from the FINNPEC cohort.

This study identifies fast and slow gene expression changes in human blood after acute social stress, revealing distinct immune cell-related transcriptional responses and potential molecular mechanisms linking stress to psychiatric disorders.

The paper integrates multi-omics data to identify regulatory networks driving human dopaminergic neuron differentiation and highlights key transcription factors and enhancer-associated regulators.

The paper creates a transcription-based atlas of canine regulatory elements across tissues and development, identifying promoters and enhancers and their activity patterns.

The paper provides the full-length sequence of DUXC mRNA from bovine embryos and investigates its genomic organization and expression patterns.

This study traces the geographic origin of a Finnish founder variant causing gelsolin amyloidosis using haplotype sharing trees and estimates its most recent common ancestor.

This study identifies maternal and fetal genetic contributions to preeclampsia through genome-wide association analyses, revealing distinct genetic architectures and biological pathways.

This study shows that hypoxia (6% O2) improves blastocyst formation in bovine embryos compared to normoxia (20% O2) and ultrahypoxia (2% O2), with normoxia altering energy metabolism and reducing blastocyst rates.

The paper evaluates the impact of different Cell Ranger versions on single-cell gene expression data, finding significant variations in cell barcode processing, gene expression, and clustering results.

The paper investigates how primary cilia influence human neuron differentiation via the WNT signaling pathway, identifying a critical 'ciliary time window' for axon development.

This study conducts a GWAS of preeclampsia and hypertensive disorders of pregnancy, identifying 18 genome-wide significant loci, including novel associations with blood pressure and placental function.

The paper identifies regulatory modules controlling dog color patterns and shows their evolutionary origin in extinct canids.

The paper identifies cis-interacting lncRNAs and their targets using RNA-chromatin and Hi-C data across 18 human cell types.

The paper introduces LUHMES, a ciliated human neuronal cell model, and shows its utility for studying cilia biology and ciliopathies across neuronal development.

The paper identifies rare variants in dynein heavy chain genes in two individuals with situs inversus and developmental dyslexia, suggesting a potential link between dynein dysfunction and these conditions.

This study shows that DUX4 regulates the oocyte-to-embryo transition in humans by activating enhancers and promoting genome reprogramming.

The paper introduces SkewC, a method to identify poor quality cells in scRNA-seq by analyzing gene coverage skewness, and validates it across 37,993 cells from 15 protocols.

The paper analyzes complement molecule expression and deposition in human pre-implantation embryos, showing complement activation and defense mechanisms at early stages of development.

The paper develops NET-CAGE to detect nascent RNA 5-ends, identifies enhancer-promoter pairs, and reveals topological connections of cis-regulatory elements across cell types.

The paper identifies a conserved DNA motif bound by PLAG1 that regulates zygotic genome activation in mice and humans, affecting early embryo development.

The paper conducts a GWAS to identify genetic variants associated with a cognitive predictor of dyslexia, finding significant associations with variants near MIR924HG and NKAIN3.

TAC-seq is a targeted sequencing method using UMIs to count biomarker molecules, showing improved accuracy in mRNA, microRNA, and cell-free DNA analysis compared to standard sequencing.

The paper analyzes single-cell RNA sequencing data from early human embryos to identify DUX4 as an early regulator of transcription during preimplantation development.