PhysiologybioRxivPreprint
High-fat diet ablates an insulin-responsive pool of GLUT4 glucose transporters in skeletal muscle
Youjia Hu, Stacey N. Brown, Ali R. Nasiri…·Jonathan S. Bogan
This study shows that high-fat diet reduces Usp25m in mice, impairing TUG cleavage and glucose uptake during fasting, leading to insulin resistance in skeletal muscle.
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