Ali R. Nasiri

This study shows that high-fat diet reduces Usp25m in mice, impairing TUG cleavage and glucose uptake during fasting, leading to insulin resistance in skeletal muscle.

Cholesterol accumulation in hepatic lipid droplets drives inflammation and fibrosis in mouse and human MASH and is reversed by inhibiting cholesterol synthesis or knocking down Coasy or Hsd17b13.

This study identifies latrophilin-2 as an upstream mechanosensor for fluid shear stress in endothelial cells, linking it to vascular development and disease.