Author
Carnegie Mellon UniversityORCID 0000-0001-7587-2303Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Gemma May, Christina Akirtava, C. Joel McManus
A back-splicing circRNA reporter yields linear trans-spliced artifacts; in orthogonal assays three reported cellular IRESes are inactive, and Iso-Seq 5' ends agree with nAnT-iCAGE start sites.
Christina Akirtava, Gemma E. May, C. Joel McManus
The paper quantifies the impact of cis-regulatory features in yeast transcript leaders on gene expression using MPRAs and identifies key sequence elements influencing translation and mRNA stability.
Gemma E. May, Christina Akirtava, Matthew Agar-Johnson…·C. Joel McManus
The paper quantifies yeast uORF activity using reporter assays and machine learning, showing sequence and position both strongly influence uORF function.
Christina Akirtava, Gemma E. May, C. Joel McManus
The paper challenges the functional significance of IRESes in Hox gene hTLs by showing they are not conserved and instead function as transcriptional promoters.