Explainable Machine Learning and Epigenomic Profiling Decipher the Topological Determinants of Lentiviral Integration and Longitudinal Persistence in SCID-X1 Gene Therapy
Zahra Mousavipour, Hamidreza Saber
The paper uses machine learning and epigenomic profiling to identify determinants of lentiviral integration and persistence in SCID-X1 gene therapy, finding significant depletion of persistent clones near proto-oncogenes.