The paper introduces an enhanced pipeline for multi-omic integration using topological data analysis to rank genes by disease relevance, validated on TCGA breast cancer data.

bioRxiv · Sep 25, 2026 · PreprintBioinformatics

Mechanotransduction and inflammation: an updated comprehensive representation

Vennila Suriyagandhi, Ying Ma, Veronica Paparozzi, Tiziana Guarnieri, Biagio Di Pietro, Giovanna Maria Dimitri, Paolo Tieri, Claudia Sala, Darong Lai, Christine Nardini

The paper provides a unified pathway representation of mechanotransduction and inflammation using SBML and network biology approaches, highlighting RAC1 as a potential therapeutic target.

Mechanobiology in Medicine · Dec 14, 2024Peer-reviewedBioinformatics

Differential Anti-Inflammatory Effects of Electrostimulation in a Standardized Setting

Biagio Di Pietro, Simona Villata, Simeone Dal Monego, Margherita Degasperi, Veronica Ghini, Tiziana Guarnieri, Anna Plaksienko, Yuanhua Liu, Valentina Pecchioli, Luigi Manni, Leonardo Tenori, Danilo Licastro, Claudia Angelini, Lucia Napione, Francesca Frascella, Christine Nardini

This study investigates the anti-inflammatory effects of different electrical stimuli on a 3D bioconstruct using transcriptomics and metabolomics, finding that 5V direct current shows promise.

bioRxiv · Jul 5, 2024 · PreprintSystems Biology