Claudia Angelini

This study identifies regulatory sequences of the Tbx1 gene and shows their deletion disrupts cardiopharyngeal lineage specification and embryonic patterning, leading to pharyngeal defects.

The paper investigates the role of Tbx1 in cardiopharyngeal mesoderm differentiation and morphogenesis, finding it stabilizes transcriptional profiles and regulates a conserved gene module.

The paper identifies genetic and non-genetic factors influencing genomic imprinting by analyzing methylation patterns in iDMRs across a large cohort of individuals.

This study investigates the anti-inflammatory effects of different electrical stimuli on a 3D bioconstruct using transcriptomics and metabolomics, finding that 5V direct current shows promise.

The paper identifies endothelial regulatory elements associated with cardiopharyngeal lineage differentiation using chromatin remodeling data, gene expression, and machine learning.

The paper shows that Minoxidil treatment reduces cardiac outflow tract septation defects in a Tbx1 mutant mouse model of DiGeorge syndrome by inhibiting collagen cross-linking.

This study shows that Tbx1 haploinsufficiency in mice causes brain metabolic and behavioral issues, which are partially reversed by vitamin B12 treatment.

The study corrects DNMT3B mutations in ICF1 iPSCs and finds that while most hypomethylated regions are restored, some regions remain hypomethylated and show increased H3K4me3 and CTCF motifs.

The paper identifies lineage regionalization defects in a mouse model of DiGeorge syndrome using vitamin B12 treatment and shows that SLUG+ cells are mislocalized and partially rescued by treatment.

This study identifies a Tbx1-dependent multilineage primed population in the murine cardiopharyngeal mesoderm using single-cell RNA-sequencing and shows its role in cardiac and skeletal muscle development.

Easyreporting simplifies implementing reproducible research layers in R software by enabling report creation without R Markdown knowledge and automatic tracking of analysis steps.

This study examines the transcriptional and chromatin changes in mouse cells lacking TBX1, finding significant transcriptional effects but limited chromatin remodeling.