Opto-chemogenetic inhibition of L-type CaV1 channels in neurons through a membrane-assisted molecular linkage
Jinli Geng, Yaxiong Yang, Boying Li, Zhen Yu, Shuang Qiu, Wen Zhang, Shixin Gao, Nan Liu, Yi Liu, Bo Wang, Yubo Fan, Chengfen Xing, Xiaodong Liu
This paper develops a method to inhibit L-type CaV1 channels in neurons using opto-chemogenetic tools, showing acute and potent inhibition through membrane-assisted molecular linkage.
Cell Reports Methods · Nov 1, 2024Peer-reviewedBioengineering