Francis Leblanc

This paper shows deep learning models outperform baselines when using well-calibrated metrics for genetic perturbation prediction.

The paper identifies LIPTER, a cardiomyocyte-specific long noncoding RNA, and shows it regulates cytoskeletal maturation and is controlled by a cardiomyocyte-specific enhancer.

This paper identifies SB000, a single gene factor that rejuvenates cells from multiple germ layers without inducing pluripotency, rivaling the effectiveness of Yamanaka factors.

The paper identifies limitations in current methods for inferring regulatory links between cCREs and genes in multiomic data, showing that cell-type-specific correlations affect null distributions and power.

This study profiles transcriptomic changes in canine atrial fibrillation models at disease onset, identifying novel genes and pathways involved in AF pathophysiology.