Stanley Nattel

Resistance to Atrial Fibrillation Domestication and Mitochondrial Dysfunction in Sheep: a potential key role of the TCA Cycle and mitochondrial redox state

This study compares mitochondrial function and TCA cycle activity in sheep resistant to atrial fibrillation (AF) versus those that develop stable AF, finding differences in redox state and energy metabolism.

Network-Based Analysis of Human Astrocytes Links Aging to Neurodegenerative and Cardiovascular Diseases

The paper identifies a 127-gene core network in human astrocytes linking aging to neurodegenerative and cardiovascular diseases through proteostasis and stress signaling.

Time-dependent Mitochondrial Remodeling in Experimental Atrial Fibrillation and Potential Therapeutic Relevance

This study examines mitochondrial changes during atrial fibrillation in animals and humans, showing early hyperfunction and damage, and demonstrates that mitochondrial-targeted therapy can prevent adverse remodeling and AF sustainability.

Revealing Shared Proteins and Pathways in Cardiovascular and Cognitive Diseases Using Protein Interaction Network Analysis

The paper identifies shared proteins and pathways between cardiovascular and cognitive diseases using protein interaction network analysis, highlighting oxidative and glycative stress mechanisms in vascular cognitive impairment.

Transcriptomic profiling of atrial fibrillation canine models at disease onset

This study profiles transcriptomic changes in canine atrial fibrillation models at disease onset, identifying novel genes and pathways involved in AF pathophysiology.