Matthew W Pearson

This paper identifies 22,411 reproducible genetic signatures associated with ME in DecodeME cohorts and finds significant overlap with long COVID genes, suggesting shared mechanisms but distinct diseases.

This study reproduces genetic risk factors for long COVID identified in a European ancestry cohort across ancestrally diverse populations, showing significant enrichment of disease signatures and supporting drug repurposing candidates.

This paper identifies 73 genes associated with severe or fatigue dominant long COVID through combinatorial analysis and finds overlaps with ME/CFS and potential drug targets.

The paper introduces FIVER, a multispectral reporter for in vivo genome editing that detects NHEJ, HDR, and HITI with fluorescent read-outs, demonstrating its utility in primary cells, organoids, and in vivo models.

This study identifies 68 genetic risk factors associated with severe COVID-19 using combinatorial analysis, highlighting pathways like calcium signaling and potential drug targets.

This study shows that a DISC1 mutation linked to mental illness disrupts NMDAR dynamics and synaptic function in neurons, affecting excitatory synapses and vesicle dynamics.