Jason M. Sardell

Identification of Novel Reproducible Combinatorial Genetic Risk Factors for Myalgic Encephalomyelitis in the DecodeME Patient Cohort and Commonalities with Long COVID

This paper identifies 22,411 reproducible genetic signatures associated with ME in DecodeME cohorts and finds significant overlap with long COVID genes, suggesting shared mechanisms but distinct diseases.

Identification and Reproducibility of Novel Combinatorial Genetic Risk Factors for Endometriosis across UK and US Patient Cohorts

This paper identifies and validates novel combinatorial genetic risk factors for endometriosis in UK and US cohorts, showing high reproducibility across diverse populations.

Reproducibility of Genetic Risk Factors Identified for Long COVID using Combinatorial Analysis Across US and UK Patient Cohorts with Diverse Ancestries

This study reproduces genetic risk factors for long COVID identified in a European ancestry cohort across ancestrally diverse populations, showing significant enrichment of disease signatures and supporting drug repurposing candidates.

Actively Protective Combinatorial Analysis: a Scalable Novel Method for Detecting Variants that Contribute to Reduced Disease Prevalence in High-Risk Individuals

This paper introduces a method to detect genetic variants that reduce disease risk in high-risk individuals, identifying protective signatures that could inform drug targets and precision medicine.

Genetic Risk Factors for Severe and Fatigue Dominant Long COVID and Commonalities with ME/CFS Identified by Combinatorial Analysis

This paper identifies 73 genes associated with severe or fatigue dominant long COVID through combinatorial analysis and finds overlaps with ME/CFS and potential drug targets.