Regulatory mechanisms in multiple vascular diseases locus LRP1 involve repression by SNAIL and extracellular matrix remodeling
Lu Liu, Joséphine Henry, Yingwei Liu, Charlène Jouve, Adrien B. Georges, Nabila Bouatia‐Naji
This study identifies rs11172113 as the causal variant in LRP1 for vascular diseases and shows SNAIL represses LRP1 expression, leading to extracellular matrix remodeling through TGF-β signaling.
bioRxiv · May 9, 2023 · PreprintMolecular Biology