Charlène Jouve

This study investigates the pathogenic effects of the DES p.R406W mutation, showing it causes electrical and structural heart remodeling linked to arrhythmias and sudden cardiac death.

This study investigates how the LMNA p.H222P mutation causes heart failure by impairing mitochondrial calcium uptake in human cardiac cells.

This study evaluates mavacamten's effects on energy balance in RASopathy-associated HCM using hiPSC-CMs with a BRAF mutation.

This study shows that structured alignment of cardiomyocytes improves mitochondrial function and bioenergetic efficiency, highlighting the role of cellular organization in heart health.

This study identifies rs11172113 as the causal variant in LRP1 for vascular diseases and shows SNAIL represses LRP1 expression, leading to extracellular matrix remodeling through TGF-β signaling.