Cancer BiologybioRxivPreprint
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eIF4E and Ezrin cooperate in pseudopods to drive a localized migratory translation program in acute myeloid leukemia
Biljana Čuljković, Leandro Marcelo Martinez, Naiyu Shi…·Katherine L. B. Borden
In acute myeloid leukemia, Ezrin binds eIF4E and anchors active ribosomes in pseudopods for local translation of CD44 and hyaluronan pathway proteins; eIF4E loss impairs mouse engraftment.