Author

Leandro Marcelo Martinez

Weill Cornell MedicineORCID 0000-0002-9283-5093Unclaimed ORCID profile · follow to get notified of new preprints

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Mónica L. GuzmániD· 2 shared Ailen D. Garcia-Santillan· 1 shared Aksharh Thambipillai· 1 shared Alyssa D. RetiziD· 1 shared Amy L. OlexiD· 1 shared Ashley D. HadjisiD· 1 shared Biljana ČuljkovićiD· 1 shared Caleb M. EmbreeiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

Mónica L. GuzmánORCID

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3 papers

Recent·Most cited

eIF4E and Ezrin cooperate in pseudopods to drive a localized migratory translation program in acute myeloid leukemia

Biljana Čuljković, Leandro Marcelo Martinez, Naiyu Shi, Alyssa D. Retiz, Samuel Perron, Aksharh Thambipillai, Caleb M. Embree, Winnie Yip, Vicenta Trujillo-Alonso, Emma Lassman, Marysol Chu Carty, Kata Alilovic, Sébastien Carreno, Gail J. Roboz, Mónica L. Guzmán, Katherine L. B. Borden

In acute myeloid leukemia, Ezrin binds eIF4E and anchors active ribosomes in pseudopods for local translation of CD44 and hyaluronan pathway proteins; eIF4E loss impairs mouse engraftment.

bioRxiv · Oct 2, 2026 · PreprintCancer Biology✦ In-depth digest

Tumor cell dissemination is facilitated through regulatory T cell-driven extracellular matrix remodeling

Ailen D. Garcia-Santillan, Jessanne Y. Lichtenberg, He Shen, Jasmine M. Rodriguez, Sandra Makar, Jonathan Barra, Nicholas M. Clark, Wei Du, Leandro Marcelo Martinez, Ashley D. Hadjis, Taylor Calicchia, Mikhail G. Dozmorov, Jose Javier Bravo‐Cordero, Amy L. Olex, Priscilla Y. Hwang, Paula D. Bos

This study shows Treg cells remodel the tumor ECM to promote metastasis, with matrisome signatures linked to poor survival in breast cancer.

bioRxiv · Oct 25, 2025 · PreprintCancer Biology

Total body irradiation primes CD19-directed CAR T cells against large B-cell lymphoma

Mohammad Alhomoud, Michelle Foley, Mayumi Sugita, Joshua Alexander Fein, Samuel Yamshon, Leandro Marcelo Martinez, Kai Rejeski, Maider Astorkia, Doron Betel, Renier J. Brentjens, Koen van Besien, Lorenzo Galluzzi, Olivier Boyer, J. Martinet, Silvia Chiara Formenti, Mónica L. Guzmán

This study shows that total body irradiation before CAR T cell infusion enhances their effectiveness against large B-cell lymphoma by improving cytotoxicity and survival outcomes.

bioRxiv · Mar 17, 2025 · PreprintCancer Biology