Author

Caleb M. Embree

Northwestern UniversityORCID 0000-0002-7437-4510Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Guramrit SinghiD· 2 shared Katherine L. B. BordeniD· 2 shared Naiyu Shi· 2 shared Aidan W.B. Carlile· 1 shared Aksharh Thambipillai· 1 shared Alyssa D. RetiziD· 1 shared Andreas StephanouiD· 1 shared Anton J. BlatnikiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMolecular Biology

Guramrit SinghORCID

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4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 2, 2026

✦ In-depth digest

eIF4E and Ezrin cooperate in pseudopods to drive a localized migratory translation program in acute myeloid leukemia

Biljana Čuljković, Leandro Marcelo Martinez, Naiyu Shi…·Katherine L. B. Borden

In acute myeloid leukemia, Ezrin binds eIF4E and anchors active ribosomes in pseudopods for local translation of CD44 and hyaluronan pathway proteins; eIF4E loss impairs mouse engraftment.

1 citation

humanmouse

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Molecular BiologyRNA BiologyPeer-reviewedAug 26, 2025

Direct and indirect effects of spliceosome disruption compromise gene regulation by Nonsense-Mediated mRNA Decay

Caleb M. Embree, Debadrita Paul, Andreas Stephanou, Guramrit Singh

The paper shows that disrupting the spliceosome upregulates NMD targets, with some spliceosome components directly affecting NMD.

11 citations

humanbulk RNA-seq

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Molecular BiologyNucleic Acids ResearchPeer-reviewedAug 2, 2025

Sm-site containing mRNAs can accept Sm-rings and are downregulated in Spinal Muscular Atrophy

Anton J. Blatnik, Manu Sanjeev, Jacob A. Slivka…·Arthur H.M. Burghes

The paper identifies Sm-site containing mRNAs that can accept Sm-rings and shows their downregulation in Spinal Muscular Atrophy.

DOI 10.1093/nar/gkaf794

humanmouse

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GeneticsbioRxivPreprintJul 25, 2025

Nuclear RNA cap-chaperones eIF4E and NCBP2 influence distinct mRNA fates

Jean-Clément Mars, Caleb M. Embree, Biljana-Culjkovic-Kraljacic…·Katherine L. B. Borden

The paper shows eIF4E and NCBP2 have distinct roles in nuclear mRNA processing, influencing different transcript populations and outcomes.

3 citations

multiomestatistical model

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