PhysiologySciencePeer-reviewed
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Ablation of Prdm16 and beige fat causes vascular remodeling and elevated blood pressure
Mascha Koenen, Tobias Becher, Giulia Pagano…·Paul Cohen
Adipocyte-specific deletion of Prdm16 ablates beige fat identity, derepresses the secreted enzyme Qsox1, and induces vascular fibrosis, angiotensin II hyperreactivity, and elevated blood pressure in mice.