Paul Cohen

This study uses single-cell multi-omics to identify OTP and NOVA1 as key regulators of leptin action in hypothalamic feeding circuits, revealing cell-type-specific transcriptional and regulatory changes.

This study shows that activating perivascular thermogenic fat reduces aortic stenosis in mice and correlates with less severe AS in humans.

This paper identifies SLC25A34 as a key regulator of interorganellar lipid cycling, integrating circadian rhythms, diet, and temperature to control thermogenic metabolism.

A Cre-dependent ER-targeted TurboID knock-in mouse enables cell type-specific secretory proteomics, mapping adipocyte and hepatocyte responses to fasting, LPS and obesity, with B cells profiled at baseline.

This study identifies Slit3 fragments that coordinate neurovascular expansion and thermogenesis in brown adipose tissue by regulating angiogenesis and sympathetic innervation.

This study investigates the thermogenic adaptations of antelope ground squirrels by analyzing their genome and transcriptome under cold exposure, revealing a shift toward shivering thermogenesis.

This study investigates the role of Wisp1 in glucose homeostasis using Wisp1 knockout mice, finding improved insulin sensitivity and reduced adipose inflammation but no effect on whole-body glucose tolerance.

Adipocyte-specific deletion of Prdm16 ablates beige fat identity, derepresses the secreted enzyme Qsox1, and induces vascular fibrosis, angiotensin II hyperreactivity, and elevated blood pressure in mice.

This study examines how different exercise intensities affect the human plasma secretome and interorgan communication through multi-cohort interventions and multi-organ gene expression analysis.

This study identifies a proteomic signature in humans following acute cold exposure that correlates with cardioprotective and anti-aging effects.

This study identifies a novel target for obesity treatment by showing that inhibiting GABAergic neurons in the dorsal raphe nucleus reduces body weight in diet-induced obese mice through thermogenesis.

The paper identifies BNC2 neurons in the hypothalamus that acutely suppress food intake by inhibiting AGRP neurons and are regulated by leptin, sensory cues, and nutritional status.