William R. Reay

The paper benchmarks structural variant analysis tools on short-read WGS data, finding that ensemble pipelines significantly reduce accuracy compared to individual tools.

This study identifies genetic pleiotropy between major depressive disorder and four physical disease clusters, finding strong associations with gastrointestinal diseases and uncovering novel biological pathways.

The paper investigates genetic correlations and causal relationships between 249 circulating metabolites and 10 psychiatric conditions, identifying 1,100 trait pairings with potential clinical implications.

This paper introduces GNA, a framework that uses network modeling on GWAS data to identify genetic architecture and trait-specific biology.

This study conducts a large GWAS of retinol, identifies genetic loci, and uses MR-pheWAS to explore retinol's causal relationships with various health traits.

The paper identifies enrichment of miRNA binding site variants in psychiatric disorders and other complex traits, suggesting their functional role in disease mechanisms.

The paper identifies shared and distinct genetic associations between schizophrenia and seven other psychiatric disorders using meta-analyses and gene-set analysis.

This paper uses Mendelian randomisation to investigate the causal effect of glycaemic traits on psychiatric disorders, finding a protective effect of fasting insulin on anorexia nervosa.

The paper develops a framework to quantify common variant enrichment in clinically actionable systems for precision medicine in schizophrenia using a pharmagenic enrichment score (PES).