Murray J. Cairns

This study evaluates (E,E)-bisantrene's anti-leukemic activity in AML by showing it suppresses MYC expression and induces apoptosis across multiple models.

The paper investigates genetic correlations and causal relationships between 249 circulating metabolites and 10 psychiatric conditions, identifying 1,100 trait pairings with potential clinical implications.

This study identifies a shared genetic factor underlying brain age gaps across 30 cohorts, finding 19 SNPs and associations with health traits.

This study identifies small but consistent anatomical correlates of negative symptom dimensions in schizophrenia, linking them to prefrontal cortical thickness and limbic subcortical volumes.

This study shows bisantrene enhances the effectiveness of tyrosine kinase inhibitors in ccRCC by sustaining AKT inhibition and overcoming TKI resistance.

The paper identifies novel CNV loci and dose-dependent gene effects across six psychiatric disorders using genome-wide analysis.

The paper identifies shared and divergent genetic mechanisms across psychiatric disorders using gene-set burden analysis of copy number variants.

This study identifies genetic risk loci and factors underlying clinical subtypes of bipolar disorder using GWAS and meta-analysis.

This study conducts a large GWAS of retinol, identifies genetic loci, and uses MR-pheWAS to explore retinol's causal relationships with various health traits.

This study investigates how structural brain alterations in schizophrenia relate to network architecture, finding hub susceptibility and shared epicenters across disease stages and disorders.

This study examines structural brain heterogeneity in schizophrenia using multimodal MRI data from the ENIGMA dataset, finding higher frontotemporal heterogeneity and left parahippocampal homogeneity in patients.

This study identifies somatic copy number variants (sCNVs) in schizophrenia cases, revealing their contribution to risk and specific NRXN1 disruptions.

The paper identifies enrichment of miRNA binding site variants in psychiatric disorders and other complex traits, suggesting their functional role in disease mechanisms.

The paper identifies potential miRNA-like small RNAs in Agaricus bisporus using RNA-seq and validates them experimentally, suggesting possible interactions with human biological processes.

A genome-wide association study of 69,369 schizophrenia cases and 236,642 controls identifies 270 risk loci, prioritizes 130 genes, and links common and rare risk variants to neuronal synaptic biology.

Meta-analysis of 41,917 European-ancestry bipolar disorder cases versus 371,549 controls yields 64 risk loci (33 novel), neuronal and synaptic gene enrichment, and 15 eQTL-prioritized genes.

BrainGENIE predicts brain-tissue gene expression from peripheral blood transcriptomes, outperforming existing methods in accuracy and biological relevance.

The paper identifies shared and distinct genetic associations between schizophrenia and seven other psychiatric disorders using meta-analyses and gene-set analysis.

The paper constructs a Poly-Methylomic Profile Score (PMPS) for schizophrenia using DNA methylation data and finds it is elevated in schizophrenia cases compared to controls, but not associated with bipolar disorder or symptom severity.

This paper uses Mendelian randomisation to investigate the causal effect of glycaemic traits on psychiatric disorders, finding a protective effect of fasting insulin on anorexia nervosa.

The paper develops a framework to quantify common variant enrichment in clinically actionable systems for precision medicine in schizophrenia using a pharmagenic enrichment score (PES).

The paper introduces the Medical Genome Reference Bank, a resource of whole genome sequences and phenotypes from 2,570 healthy elderly Australians, showing fewer disease-associated variants and age-related somatic changes linked to grip strength.

This study identifies 114 genome-wide significant loci for schizophrenia and bipolar disorder, with specific subphenotype associations and four genes distinguishing the disorders.