Cancer-Associated Mutations Perturb the Structure and Interactions of the Intrinsically Disordered p53 Transactivation Domain
Lynn Goss Schrag, Xiaorong Liu, Indhujah Thevarajan, Om Prakash, Michal Žółkiewski, Jianhan Chen
This study shows cancer-associated mutations in p53-TAD disrupt its interactions with regulatory proteins by altering its disordered conformational state rather than directly breaking known interaction interfaces.
Journal of Molecular Biology · May 11, 2021Peer-reviewedMolecular Biology