Author

Xiaorong Liu

University of Massachusetts AmherstORCID 0000-0002-7687-3604Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Xiaorong Liu1 paper · Shenzhen Children's Hospital

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:protein structure· 2 Approach:comparative / phylogenetic analysis· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1

Frequent Co-Authors

Benjamin G EmmanueliD· 1 shared Charles L. BrooksiD· 1 shared Elizabeth M. MeieringiD· 1 shared Iain MH McDonaldiD· 1 shared Indhujah ThevarajaniD· 1 shared Jianhan CheniD· 1 shared Luis Benito Pérez SocasiD· 1 shared Lynn Goss SchragiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiophysics

Benjamin G EmmanuelORCID

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2 papers

Recent·Most cited

Surface electrostatic networks control hydrophobic core remodeling in a pH-dependent switching protein

Iain MH McDonald, Luis Benito Pérez Socas, Max Walton-Raaby, Xiaorong Liu, Sathish Dasari, Benjamin G Emmanuel, Mahnoor S. Butt, Subha Kalyaanamoorthy, Charles L. Brooks, Elizabeth M. Meiering

The paper investigates how surface electrostatic networks mediate pH-dependent hydrophobic core remodeling in hisactophilin through protonation changes and residue interactions.

bioRxiv · Jul 16, 2026 · PreprintBiophysics

Cancer-Associated Mutations Perturb the Structure and Interactions of the Intrinsically Disordered p53 Transactivation Domain

Lynn Goss Schrag, Xiaorong Liu, Indhujah Thevarajan, Om Prakash, Michal Žółkiewski, Jianhan Chen

This study shows cancer-associated mutations in p53-TAD disrupt its interactions with regulatory proteins by altering its disordered conformational state rather than directly breaking known interaction interfaces.

Journal of Molecular Biology · May 11, 2021Peer-reviewedMolecular Biology