Author

Lynn Goss Schrag

Kansas State UniversityORCID 0000-0002-7704-8841Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Assay:protein structure· 1

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Indhujah ThevarajaniD· 1 shared Jianhan CheniD· 1 shared Michal ŽółkiewskiiD· 1 shared Om PrakashiD· 1 shared Xiaorong LiuiD· 1 shared

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2021-2021 · peak 1/yr

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1 shared paperMolecular Biology

Indhujah ThevarajanORCID

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1 paper

Recent·Most cited

Molecular BiologyJournal of Molecular BiologyPeer-reviewedMay 11, 2021

Cancer-Associated Mutations Perturb the Structure and Interactions of the Intrinsically Disordered p53 Transactivation Domain

Lynn Goss Schrag, Xiaorong Liu, Indhujah Thevarajan…·Jianhan Chen

This study shows cancer-associated mutations in p53-TAD disrupt its interactions with regulatory proteins by altering its disordered conformational state rather than directly breaking known interaction interfaces.

24 citations

protein structureexperimental assay

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