David Roe

The paper introduces KPI, a method to accurately infer KIR genes and haplotypes from genome sequencing reads using novel k-mer signatures, achieving high accuracy on synthetic and real data.

The paper generates and aligns KIR haplotypes at high resolution, defines them as 14 loci with 9 genes, and applies the alignments in software tools for haplotype annotation and genotyping.

The paper presents a method using long-read sequencing to efficiently assemble and annotate diploid human KIR haplotypes with high accuracy and coverage.

The paper uses long-read sequencing to phase and sequence sixteen KIR haplotypes from eight individuals, revealing novel structures and variants.