Functional and dysfunctional T regulatory cell states in human tissues in RA and other autoimmune arthritic diseases
Byunghee Koh, Shani Talia Gal-Oz, Ryota Sato, Hung Nguyen, Garrett S. Dunlap, Christopher B. Mahony, Chrissy Bolton, Accelerating Medicines Partnership (AMP) RA/SLE Network, Lucy R. Wedderburn, Adam P. Croft, Laura T. Donlin, Melanie H. Smith, Soumya Raychaudhuri, Ilya Korsunsky, Deepak A. Rao, Michael B. Brenner
This study identifies two distinct Treg states in RA synovial tissues using scRNA-seq, showing one is dysfunctional and reversible through TNFR2 engagement.
Nature Immunology · Jun 16, 2026Peer-reviewedImmunology