This study shows that CHMP2A is essential for the ordered assembly of ESCRT-III proteins during cytokinetic abscission, revealing a hierarchical organization of these subunits.

Molecular Biology of the Cell · Sep 10, 2025Peer-reviewedCell Biology

AuroraB-kinase methylation by SETD6 regulates cytokinesis and protects cells from chromosomal instability

Michal Feldman, Anand Chopra, Dikla Nachmias, Kyle K. Biggar, Daniel Sevilla-Sánchez, Natalie Elia, Dan Levy

This study shows that SETD6 methylates Aurora-B kinase, regulating cytokinesis and preventing chromosomal instability, with implications for cancer.

bioRxiv · Dec 22, 2024 · PreprintCell Biology

Cytokinetic abscission is part of the mid-blastula transition switch in early zebrafish embryogenesis

Shai Adar-Levor, Dikla Nachmias, Shani Talia Gal-Oz, Yarden Mazal Jahn, Nadine Peyriéras, Assaf Zaritsky, Ramon Y. Birnbaum, Natalie Elia

The paper shows that abscission is delayed in early zebrafish embryos until midblastula transition, allowing sibling cells to remain connected and coordinate developmental timing.

Proceedings of the National Academy of Sciences · Apr 7, 2021Peer-reviewedDevelopmental Biology

Live Cell Imaging of Bioorthogonally Labelled Proteins Generated With a Single Pyrrolysine tRNA Gene

Noa Aloush, Tomer Schvartz, Andres I. König, Sarit Cohen, Eugene Brozgol, Benjamin Tam, Dikla Nachmias, Oshrit Ben‐David, Yuval Garini, Natalie Elia, Eyal Arbely

The paper shows that reducing PylT gene copies improves live-cell imaging of bioorthogonally labelled proteins without affecting protein expression.

Scientific Reports · Sep 24, 2018Peer-reviewedSynthetic Biology