GeneticsbioRxivPreprint
Mouse Homolog of Human IRF8G388S Mutation Provides Novel Insight into Osteoclastogenesis and Tooth Root Resorption
Amitabh Das, Sathish Kumar Yesupatham, Devon L. Allison…·Vivek Thumbigere‐Math
This study generates Irf8 knock-in mice modeling the human IRF8G388S mutation, showing increased osteoclast activity and tooth root resorption while sparing immune cell development.
DOI 10.1101/2023.04.23.537931