Mouse Homolog of Human IRF8G388S Mutation Provides Novel Insight into Osteoclastogenesis and Tooth Root Resorption
Amitabh Das, Sathish Kumar Yesupatham, Devon L. Allison, Himanshi Tanwar, JebaMercy Gnanasekaran, Bernice D. Kear, Xiaobei Wang, Sheng Wang, Christina Zachariadou, Yasaman Abbasi, Man‐Kyo Chung, Keiko Ozato, Chengyu Liu, Brian Lee Foster, Vivek Thumbigere‐Math
This study generates Irf8 knock-in mice modeling the human IRF8G388S mutation, showing increased osteoclast activity and tooth root resorption while sparing immune cell development.
bioRxiv · Apr 23, 2023 · PreprintGenetics