Author

Helen L. Fitzsimons

Massey UniversityORCID 0000-0001-7825-3911Unclaimed ORCID profile · follow to get notified of new preprints

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Signature Assays, Organisms & Methods

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Organism:Drosophila· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Andrew J. Sutherland‐SmithiD· 1 shared David A. WheeleriD· 1 shared Hannah R. HawleyiD· 1 shared Matthew Scott SavoianiD· 1 shared Patrick Main· 1 shared Sarah J Wilson· 1 shared Silvia SchwartziD· 1 shared Tracy K. HaleiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 9 mutual co-author links

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1 shared paperNeuroscience

Andrew J. Sutherland‐SmithORCID

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3 papers

Recent·Most cited

NeuroscienceOpen BiologyPeer-reviewedOct 1, 2025

N-terminal oligomerization drives HDAC4 nuclear condensation and neurodevelopmental dysfunction in Drosophila

Hannah R. Hawley, Andrew J. Sutherland‐Smith, Matthew Scott Savoian, Helen L. Fitzsimons

This study shows that HDAC4 nuclear condensation, driven by oligomerization and stabilized by MEF2, causes neurodevelopmental defects in Drosophila, suggesting therapeutic targets for related diseases.

3 citations

Drosophilaexperimental assay

𝕏 PostBluesky

GeneticsbioRxivPreprintJul 18, 2021

Ankyrin2 is required for neuronal morphogenesis and long-term memory and interacts genetically with HDAC4

Silvia Schwartz, Sarah J Wilson, Tracy K. Hale, Helen L. Fitzsimons

This study investigates the role of Ankyrin2 in neuronal morphogenesis and long-term memory in Drosophila, showing its interaction with HDAC4 in gamma neurons.

DOI 10.1101/2021.07.18.452850

Drosophilaexperimental assay

𝕏 PostBluesky

NeuroscienceFrontiers in Molecular NeurosciencePeer-reviewedMar 30, 2021

Increased abundance of nuclear HDAC4 impairs neuronal development and long-term memory

Patrick Main, Wei Jun Tan, David A. Wheeler, Helen L. Fitzsimons

This study shows that increased nuclear HDAC4 in Drosophila causes neuronal developmental issues and memory deficits without major transcriptional changes.

28 citations

Drosophilaexperimental assay

𝕏 PostBluesky