BiochemistryJournal of Biological ChemistryPeer-reviewed
Identification of Novel Allosteric Sites of SARS-CoV-2 Papain-Like Protease (PLpro) for the Development of COVID-19 Antivirals
Juliana C. Ferreira, Adrian J. Villanueva, Kenana Al Adem…·Wael M. Rabeh
This study identifies three potential allosteric sites on SARS-CoV-2 PLpro, evaluates their impact on proteolytic activity through alanine mutagenesis, and highlights Pockets 1 and 3 as promising targets for antiviral drug development.
19 citationstop 3%