Lei Chen

This study tracks microbiome changes across four body sites in 86 participants over six years, revealing site-specific stability, individualized dynamics, and altered patterns in insulin-resistant individuals.

The paper develops a pipeline to profile both host expression and microbial abundance from spatial transcriptomic data, demonstrating host-microbe interactions and method efficiency.

The paper develops a pipeline to analyze spatial transcriptomic data for microbial sequences, validates it on human and murine intestinal datasets, and presents initial biological insights.

The paper analyzes meta-transcriptomic data to identify gene expression and novel conserved sub-genomic RNAs in SARS-CoV-2 and MERS-CoV, revealing new peptides with potential functional roles in viral virulence.