Gut archaea drive human MAIT cell responses
Natasha Fisher-Pearson, Martin Joseph Lett, Isaac W. D. Maylam, Connor S. J. Philip, Mariolina Salio, Richard J. Suckling, Robert Alan Simmons, Keir Barnbrook, Benjamin Swift, Walter Godfrey Jaoko, Freddie Kibengo, William Kilembe, Eduard Joachim Sanders, Mark Christopher Coles, Claire F. Pearson, , Jethro S. Johnson
The paper shows that gut archaea produce 5-OP-RU, which activates MAIT cells, linking archaea to human immunity.
bioRxiv · Sep 16, 2026 · PreprintImmunology