Author

Antônio José da Silva-Gonçalves

Instituto Oswaldo CruzORCID 0000-0001-7868-8317Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2

Frequent Co-Authors

Herbert Leonel de Matos GuedesiD· 2 shared Márcia Pereira de OliveiraiD· 2 shared Alda Maria Da‐CruziD· 1 shared Alessandra Marcia da Fonseca-MartinsiD· 1 shared Alisson Amaral Da-Rocha· 1 shared Daniel Cláudio Oliveira GomesiD· 1 shared Douglas B. De-Almeida· 1 shared E VidaliD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPathology

Herbert Leonel de Matos GuedesORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Leishmania amazonensis infection induces IL1β-dependent hyperalgesia, while dampening mechanical allodynia in C57BL/6 mice

G. Pérez, Emanuelle Vasconcellos de Lima, Leticia S. Antonio, E Vidal, Raíssa Rilo Christoff, Milla Bezerra Paiva, Antônio José da Silva-Gonçalves, Márcia Pereira de Oliveira, Maria Bellio, Robson Coutinho‐Silva, Robson da Costa, Rodrigo Tinoco Figueiredo, Julia Rosauro Clarke, Herbert Leonel de Matos Guedes

This study investigates nociceptive changes in cutaneous leishmaniasis using C57BL/6 mice, finding IL-1β contributes to thermal hypersensitivity while structural changes cause mechanical desensitization.

Virulence · Oct 31, 2025Peer-reviewedPathology

Mice Mucosal Leishmaniasis model shown high parasite load, increased cytotoxicity and impaired IL-10+ cells response

Alisson Amaral Da-Rocha, Júlio Souza dos-Santos, Igor Santos Bittencourt, Douglas B. De-Almeida, Naiara Carla Manhães, Hozany Praxedes, João Victor Paiva Romano, Elias Barbosa da Silva-Júnior, Antônio José da Silva-Gonçalves, Márcia Pereira de Oliveira, Luciana Polaco Covre, Daniel Cláudio Oliveira Gomes, Alda Maria Da‐Cruz, Alessandra Marcia da Fonseca-Martins, Herbert Leonel de Matos Guedes

This study evaluates the immunopathological effects of Leishmania amazonensis infection in BALB/c mice via mucosal and dermal routes, finding higher parasite load and inflammation in the mucosa.

Frontiers in Immunology · Aug 4, 2025Peer-reviewedImmunology