J. Paul Hamilton

The paper examines how childhood maltreatment affects brain structure in 3,711 individuals with MDD and PTSD, finding age- and sex-specific brain morphometric differences.

This study identifies lifestyle, early-life, and genetic factors associated with brain age gaps in individuals with major depressive disorder compared to controls.

This study uses normative modeling to analyze cortical thickness deviations in MDD patients and healthy controls, finding large overlaps and significant heterogeneity in extreme deviations across individuals.

The paper replicates a brain age gap in depression using a large-scale multisite study, finding a similar effect size to a prior study.

The paper shows that different analysis workflows by 70 teams on the same fMRI dataset led to varied results, but meta-analysis found consensus in activated regions.

This study uses simultaneous fPET-fMRI to show reduced dopamine release and neural activity in the striatum in MDD during reward processing, with decoupling linked to rumination.