Kazufumi Mochizuki

The paper investigates the mechanism of telomere removal in Tetrahymena's germline micronucleus, showing it is part of a broader programmed DNA elimination process.

The paper identifies G/C-rich tracts as targets of non-coding RNA transcription in meiotic Tetrahymena micronuclei and shows that Rib1, an intrinsically disordered protein, facilitates this process through phase-separation.

This study shows that the SUMO E3 ligase Ema2 promotes lncRNA transcription, which is necessary for small RNA-directed DNA elimination in Tetrahymena.