This study identifies molecular factors shaping small RNA content in mouse sperm, revealing dynamics and protein associations during spermiogenesis and capacitation.

bioRxiv · Jul 31, 2026 · PreprintMolecular Biology

A SUMO E3 ligase promotes long non-coding RNA transcription to regulate small RNA-directed DNA elimination

Salman Shehzada, Tomoko Noto, Julie Saksouk, Kazufumi Mochizuki

This study shows that the SUMO E3 ligase Ema2 promotes lncRNA transcription, which is necessary for small RNA-directed DNA elimination in Tetrahymena.

eLife · Jan 10, 2024Peer-reviewedMolecular Biology

tRNA 2-O-methylation modulates small RNA silencing and life span in Drosophila.

Margarita T. Angelova, Dilyana G. Dimitrova, Bruno Da Silva, Virginie Marchand, Caroline Jacquier, Cyrinne Achour, Mira Brazane, Catherine Goyenvalle, Valérie Bourguignon‐Igel, Salman Shehzada, Souraya Khouider, Tina Lenče, Vincent Guérineau, Jean‐Yves Roignant, Christophe Antoniewski, , Clément Carré

This study identifies two tRNA methyltransferases in Drosophila that modulate small RNA silencing and lifespan by modifying specific tRNAs.

Nucleic Acids Research · Jan 9, 2020Peer-reviewedMolecular Biology