Cancer BiologybioRxivPreprint
PRC2 Restricts Malignant Peripheral Nerve Sheath Tumorigenesis in a Genetically Engineered Mouse Model of MPNST
Woo Hyun Cho, Amish J. Patel, Makzhuna Khudoynazarova…·Ping Chi
This study shows that PRC2 inactivation promotes MPNST by reprogramming Schwann-lineage cells and presents a mouse model that recapitulates human PRC2-loss MPNST.