Juan Yan

Evasion of Hepatic ILC1 Immunosurveillance Drives Breast Cancer Liver Metastasis

This study identifies liver-resident ILC1s as a critical barrier against breast cancer liver metastasis, showing that DR5 expression and host metabolism influence this immunosurveillance.

PRC2 Restricts Malignant Peripheral Nerve Sheath Tumorigenesis in a Genetically Engineered Mouse Model of MPNST

This study shows that PRC2 inactivation promotes MPNST by reprogramming Schwann-lineage cells and presents a mouse model that recapitulates human PRC2-loss MPNST.

BET inhibitors as a therapeutic intervention in gastrointestinal gene signature-positive castration-resistant prostate cancer.

This study identifies BET inhibitors as effective against GI transcriptome-positive CRPC by targeting HNF1A and HNF4G, improving outcomes in preclinical models.