Author

Cristina R. Antonescu

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-9717-8205Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Approach:deep learning· 2 Approach:experimental assay· 2

Frequent Co-Authors

Cindy J. LeeiD· 2 shared Dan LiiD· 2 shared Dana M. Schoeps· 2 shared Kae Kristoff· 2 shared Mohini R. PachaiiD· 2 shared Ping ChiiD· 2 shared Woo Hyun ChoiD· 2 shared Yu CheniD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

Cindy J. LeeORCID

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5 papers

Recent·Most cited

MYC drives endothelial transformation and dedifferentiation in angiosarcoma

Chen Khuan Wong, Dan Li, Tomer Itkin, Cindy J. Lee, Nicholas A. Teri, Jiasheng Zhou, Dana M. Schoeps, Nikita R. Staniloae, Mohini R. Pachai, Makhzuna N. Khudoynazarova, Priya Pancholi, Woo Hyun Cho, Gabriella Bayshtok, Kae Kristoff, Selina Fan, , Yu Chen

This study shows MYC drives endothelial transformation and dedifferentiation in angiosarcoma by promoting lineage plasticity and cell growth.

bioRxiv · Oct 9, 2026 · PreprintCancer Biology

SRF fusion oncogenes encode constitutively activated chimeric transcription factors in myoid soft tissue tumors

Constance Pirson, Ariane Sablon, Axelle E. Loriot, Pierre Autin, Arie Koen Braat, Marie Karanian, Cristina R. Antonescu, Franck Tirode, Jean‐Baptiste Demoulin

Cellular and Molecular Life Sciences · Aug 26, 2026Peer-reviewedCancer Biology

A deep-learning tool for species-agnostic integration of cancer cell states

Jonathan Rub, Jason Earl Chan, Carleigh Sussman, Gary Guzman, William D. Tap, Cristina R. Antonescu, Samuel Singer, Tuomas Tammela, Doron Betel

scVital integrates scRNA-seq data across species to identify conserved cell states and reduce batch effects using a variational autoencoder and discriminator.

Cancer Research · Nov 12, 2025Peer-reviewedCancer Biology

PRC2 Restricts Malignant Peripheral Nerve Sheath Tumorigenesis in a Genetically Engineered Mouse Model of MPNST

Woo Hyun Cho, Amish J. Patel, Makzhuna Khudoynazarova, Sarah Warda, Juan Yan, Dan Li, Dana M. Schoeps, Eve Fishinevich, Mohini R. Pachai, Cindy J. Lee, Zoe Jacobs, Kae Kristoff, Jessica J. Sher, Cristina R. Antonescu, Yu Chen, Ping Chi

This study shows that PRC2 inactivation promotes MPNST by reprogramming Schwann-lineage cells and presents a mouse model that recapitulates human PRC2-loss MPNST.

bioRxiv · Nov 12, 2025 · PreprintCancer Biology

Integrated histopathologic modeling of detailed tumor subtypes and actionable biomarkers

Kevin M Boehm, Madison Darmofal, Arfath Pasha, Andrew T. Aukerman, Raymond S. Lim, Evan Seffar, Tom Pollard, Natasha Rekhtman, Jason C. Chang, Armaan Kohli, Darin Moore, Marta Ligero, Jianjiong Gao, Georgios Asimomitis, Anika Begum, , Francisco Sánchez-Vega

The paper develops Mosaic, a machine learning system that classifies tumors into detailed subtypes and identifies molecular phenotypes using histopathologic and genomic data from a large patient cohort.

bioRxiv · Aug 14, 2025 · PreprintCancer Biology