BiochemistrybioRxivPreprint
Covalent remodeling of CRBN creates a non-canonical neosubstrate interface with NTAQ1
Andres H. de la Peña, Justin T. Cruite, Jianwei Che…·Lyn H. Jones
The paper shows that covalent modification of CRBN by EM12-FS creates a new interface for NTAQ1 recruitment, expanding degrader specificity beyond the G-loop degron.
DOI 10.64898/2026.07.14.738385