Andres H. de la Peña

Covalent remodeling of CRBN creates a non-canonical neosubstrate interface with NTAQ1

The paper shows that covalent modification of CRBN by EM12-FS creates a new interface for NTAQ1 recruitment, expanding degrader specificity beyond the G-loop degron.

Molecular glue CELMoD compounds are allosteric regulators of cereblon conformation

This study investigates how CELMoD compounds induce conformational changes in cereblon, enabling neosubstrate binding and informing drug design strategies.

Structures of the substrate-engaged 26S proteasome reveal the mechanisms for ATP hydrolysis-driven translocation

The paper presents cryo-EM structures of the 26S proteasome in four conformational states to elucidate how ATP hydrolysis drives substrate translocation and deubiquitination.