Zhipeng Hou

This paper describes the creation of a novel HD mouse model, BAC226Q, which accurately recapitulates age-dependent and progressive HD-like phenotypes.

This paper develops a registration technique for aligning 3D MRI and histology images in Alzheimer’s disease, handling intensity differences and missing data, and applies it to map tau tangles in brain tissue.

This study shows that the cortico-striatal circuit regulates sensorimotor gating through Disc1/Huntingtin-mediated Bdnf transport, with lithium restoring deficits in Disc1-LI mice.