Akira Sawa

The paper demonstrates a non-invasive nasal swab platform with single-cell Western blotting for Alzheimer's disease biomarker detection, showing superior diagnostic performance compared to blood-based methods.

This paper presents a novel monkey model with impaired DISC1 gene to study adolescent prodromal phenotypes of psychiatric disorders, finding altered social behavior and disrupted brain connectivity.

This study examines how different SETD1A mutations and genetic backgrounds affect human hippocampal neurons derived from hiPSCs, revealing divergent molecular and cellular phenotypes and contrasting mutation impacts.

This study identifies the role of anterior insular cortex neurons in higher-order threat learning and memory, showing they are essential for temporally separated or diffuse threat contexts but constrain fear expression during retrieval.

Ultra-rare damaging coding variants in 87,959 schizophrenia cases and 150,587 controls implicate 40 genes (16 exome-wide, 24 at 5% FDR), half overlapping autism, developmental delay or bipolar genes.

NeuroFLAME provides a secure, scalable federated platform for multi-site neuroimaging analysis, achieving consistency with centralized methods while preserving data privacy and enabling institutional compliance.

This study shows that astrocyte redox imbalance causes neuronal hypoactivity and affective behaviors in epilepsy, distinct from seizure mechanisms.

This study identifies nuclear GAPDH translocation as a mediator of stress-induced cardiac hypertrophy through BRG1-associated chromatin remodeling in mice and human patients.

This study identifies the role of CMV viral protein IE1 in disrupting host DISC1-PML interaction, leading to neural progenitor deficits in congenital CMV infection.

The paper identifies attenuated CaV1.2-BK channel protein interaction in bipolar disorder patients and shows its role in intracellular calcium dynamics and cycling behavior.

This study examines white matter changes in schizophrenia patients over two to three years post-onset and finds no longitudinal differences but links white matter alterations to negative symptoms.

The paper presents a WM intrinsic connectivity network template derived from 100,000 fMRI scans, showing distinct WM and GM networks with task-related activity and differences in schizophrenia.

This study identifies a soluble synaptic protein, 2{delta}-1, reduced in schizophrenia CSF, which enhances neuronal network dynamics and cognitive function when administered to a mouse model.

This study investigates GABAergic neuron dysfunction in psychiatric disorder models, finding mutation-dependent synaptic deficits and shared gene expression changes in DISC1 mutant neurons.

The paper identifies neuroimaging alterations associated with relapse in early-stage psychosis by analyzing resting-state functional connectivity in a cross-sectional study.

This study investigates how inflammation in the olfactory epithelium affects the olfactory bulb in schizophrenia and related disorders, finding correlations between immune-related gene expression and OB volume reduction.

This study introduces SSB+SWPC, a method that improves time-resolved functional connectivity analysis by reducing high-pass filtering effects, showing better performance in both simulated and real fMRI data.

This study shows that adolescent THC exposure causes microglial apoptosis in the mPFC, which is worsened by 16p11.2 duplication, leading to social memory deficits via microglial Cnr1.

This study uses 7-Tesla MRS to track longitudinal changes in brain metabolites in FEP patients and healthy controls, identifying potential trait and state markers for psychosis.

This paper introduces ST-Cal-Light, a method to tag active neurons by converting somatic calcium signals into gene expression, enabling precise functional circuit analysis.

This study identifies the miR-124-AMPAR pathway as a common mediator linking polygenic risks to shared behavioral changes in schizophrenia and bipolar disorder.

This study characterizes olfactory neuronal cells from nasal biopsies using single-cell and bulk RNA sequencing, showing their neuronal similarity and utility in brain disorder research.

The paper develops a reliable network template and methods to estimate individualized functional networks from resting-state fMRI data across 100k+ individuals, showing how data length and spatial resolution affect network estimation.

This study identifies the nuclear GAPDH cascade in microglia as a mediator of stress-induced cognitive inflexibility and shows that targeting it can normalize cognitive deficits.

This study identifies DISC1 as a key molecule for cardiomyocyte resilience after myocardial infarction, showing its role in cardioprotection through interaction with GSK3β and its relevance in cardiac health following coronary artery bypass grafting.

This paper introduces PRS-CSx, a method that improves polygenic prediction across ancestrally diverse populations by integrating GWAS summary statistics and sharing genetic effects.

This study shows that prenatal immune stress leads to long-term reduced microglia activation, affecting striatal connectivity and neuronal function.

This study identifies the role of the anterior insular cortex in associating temporally discontiguous stimuli during threat learning in mice.

This study shows that adolescent stress leads to prolonged HPA axis dysregulation and postpartum depression, with a GR antagonist showing therapeutic potential in mice and humans.

This study examines face processing deficits in first episode psychosis patients and links them to reduced resting-state functional connectivity and volume in the right subcallosal anterior cingulate cortex.