Molecular BiologybioRxivPreprint
Single-Molecule Imaging Reveals Transcription-Driven Supercoiling in Unconstrained DNA
Lili Yang, Yanran Wang, Wei Lyu…·Enoch Yeung
The paper shows that transcription by RNAP generates and confines supercoiling in unconstrained DNA through dynamic topological domains.
DOI 10.1101/2025.11.08.687369