Enoch Yeung

Inhibitory Fc Receptor sets a time limit on macrophage response to IgG

The paper shows that inhibitory Fc{gamma}RIIB limits macrophage signaling duration, while activating Fc receptors control sensitivity, using chimeric receptors and in silico modeling.

Tuning a Genetic Circuit with Double Negative Feedforward Loops to Approximate Square Waves

This paper designs a genetic circuit with double negative feedforward loops to generate square-wave gene expression with independently tunable amplitude and duration.

Single-Molecule Imaging Reveals Transcription-Driven Supercoiling in Unconstrained DNA

The paper shows that transcription by RNAP generates and confines supercoiling in unconstrained DNA through dynamic topological domains.

Topoisomerase Based Control of Cellular Transcription and Growth

The paper develops a stochastic model of transcriptional responses to DNA supercoiling and demonstrates its control implications using an E. coli temperature-sensitive mutant.

Disentangling gene expression burden identifies generalizable phenotypes induced by synthetic gene networks

The paper identifies synthetic gene network-induced phenotypes by analyzing gene expression in E. coli and validates them through antibiotic resistance experiments.

Learning perturbation-inducible cell states of novel compounds from observability analysis of transcriptome dynamics

The paper develops a machine learning approach to identify perturbation-inducible genes from time-series RNA-seq data, applying it to discover malathion-responsive promoters in Pseudomonas fluorescens.

Prediction of Whole-Cell Transcriptional Response with Machine Learning

The paper introduces a machine learning model to predict whole-cell transcriptional responses to combinations of perturbations using data from single inducers.

Data-Driven Network Models for Genetic Circuits From Time-Series Data with Incomplete Measurements

This paper introduces dynamical structure functions to model genetic circuits from time-series data with incomplete measurements, demonstrating their ability to explain failure modes in genetic circuits.

A broad-host-range event detector: expanding and quantifying performance across bacterial species

This study evaluates a chemical event logger's performance across different bacterial species, finding that Pseudomonads outperform E. coli in some aspects.

Implementation and System Identification of a Phosphorylation-Based Insulator in a Cell-Free Transcription-Translation System

This paper implements a phosphorylation-based insulator in a cell-free system and identifies its structural parameters to reduce retroactivity.

The Effect of Compositional Context on Synthetic Gene Networks

This study shows that compositional context in synthetic gene networks significantly affects gene expression levels and key regulatory properties.

A cell-free framework for biological systems engineering

This paper demonstrates that synthetic gene networks can be designed, characterized, and engineered in a cell-free system and successfully transferred to living cells, showing their applicability in both in vitro and in vivo contexts.

Synthetic logic circuits using RNA aptamer against T7 RNA polymerase

This paper demonstrates the use of an RNA aptamer against T7 RNA polymerase to create synthetic logic circuits and transcriptional cascades in E. coli.