PhysiologybioRxivPreprint
Gene Therapy with the N-terminal Fragment of Nav1.5 for Cardiac Channelopathies: A Novel Transcomplementation Mechanism Potentiating the Cardiac Sodium Current
Marie Gizon, Marine C. Ferrand, Vincent Fontaine…·Nathalie Neyroud
This paper demonstrates that overexpressing the N-terminal fragment of Nav1.5 restores cardiac sodium current and electrical activity in models of Brugada syndrome.