Vincent Fontaine

CardioShift resolves cell-to-cell functional heterogeneity in hiPSC-derived cardiomyocytes by accounting for nested variance, revealing hidden subpopulations and condition-dependent phenotypes.

This paper demonstrates that overexpressing the N-terminal fragment of Nav1.5 restores cardiac sodium current and electrical activity in models of Brugada syndrome.

This study shows that CASK depletion improves intercalated disc organization and ventricular function in multiple models, suggesting CASK as a repressor of ID structure and function in cardiac disease.

This study performs a large GWAS on dilated cardiomyopathy, identifying two new loci and confirming two existing ones, with potential therapeutic implications.