Catalytic regulation of CoA transferase by an NAD+-sensing accessory protein and protein acetylation
Ayako Yoshida, Hiroyuki Yamamoto, Tomoko Miyata, Takeo Tomita, Minoru Yoshida, Keiichi Namba, Saori Kosono, Makoto Nishiyama
This study identifies a dual regulatory mechanism for a CoA transferase in Thermus thermophilus, controlled by NAD+-sensing and acetylation, which fine-tunes β-oxidation flux based on cellular metabolic states.
bioRxiv · Oct 31, 2025 · PreprintBiochemistry