Molecular BiologyGenes & DevelopmentPeer-reviewed
Functional divergence of Capicua isoforms explains differential tissue vulnerability in neurological disease
Hamin Lee, Esmeralda Villavicencio Gonzalez, Elias M. Rivera…·Huda Yahya Zoghbi
The paper shows that different isoforms of CIC interact with paralogs ATXN1 and ATXN1L, leading to distinct phenotypes and explaining tissue-specific vulnerability in neurological diseases.
DOI 10.1101/gad.353596.125